Ethanol induced hepatic mitochondrial dysfunction is attenuated by all trans retinoic acid supplementation.

@article{Nair2015EthanolIH,
  title={Ethanol induced hepatic mitochondrial dysfunction is attenuated by all trans retinoic acid supplementation.},
  author={Saritha S Nair and P. S. Prathibha and S. Rejitha and M Indira},
  journal={Life sciences},
  year={2015},
  volume={135},
  pages={101-9}
}
AIMS Alcoholics have reduced vitamin A levels in serum since vitamin A and ethanol share the same metabolic pathway. Vitamin A supplementation has an additive effect on ethanol induced toxicity. Hence in this study, we assessed the impact of supplementation of all trans retinoic acid (ATRA), an active metabolite of vitamin A on ethanol induced disruptive alterations in liver mitochondria. METHODS Male Sprague Dawley rats were grouped as follows: I: Control; II: Ethanol (4 g/kg b.wt./day); III… CONTINUE READING