Ethanol-induced conditioned place preference, but not aversion, is blocked by treatment with d-penicillamine, an inactivation agent for acetaldehyde

@article{Font2005EthanolinducedCP,
  title={Ethanol-induced conditioned place preference, but not aversion, is blocked by treatment with d-penicillamine, an inactivation agent for acetaldehyde},
  author={Laura Font and Carlos M. G. Aragon and Marta Miquel},
  journal={Psychopharmacology},
  year={2005},
  volume={184},
  pages={56-64}
}
There is evidence to suggest that acetaldehyde is involved in the control of ethanol-seeking behavior and reward. d-penicillamine, a thiol amino acid, is a highly selective agent for the inactivation of acetaldehyde. Previous studies from our laboratory have demonstrated that d-penicillamine prevents both behavioral stimulation induced by ethanol and acetaldehyde-produced locomotor depression in mice. The contribution of ethanol-derived acetaldehyde to the affective effects of ethanol… CONTINUE READING
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Interstimulus interval determines whether ethanol produces conditioned place preference or aversion

  • CL Cunningham, DM Okorn, CE Howard
  • Animal Learn Behav
  • 1997
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