Ethanol induced acetylation of histone at G9a exon1 and G9a-mediated histone H3 dimethylation leads to neurodegeneration in neonatal mice.

@article{Subbanna2014EthanolIA,
  title={Ethanol induced acetylation of histone at G9a exon1 and G9a-mediated histone H3 dimethylation leads to neurodegeneration in neonatal mice.},
  author={Shivakumar Subbanna and Nagaraja N. Nagre and Madhu Shivakumar and Nagavedi Siddaramappa Umapathy and Delphine Psychoyos and Balapal S Basavarajappa},
  journal={Neuroscience},
  year={2014},
  volume={258},
  pages={422-32}
}
The transient exposure of immature rodents to ethanol during postnatal day 7 (P7), comparable to a time point within the third trimester of human pregnancy, induces neurodegeneration. However, the molecular mechanisms underlying the deleterious effects of ethanol on the developing brain are poorly understood. In our previous study, we showed that a high dose administration of ethanol at P7 enhances G9a and leads to caspase-3-mediated degradation of dimethylated H3 on lysine 9 (H3K9me2). In this… CONTINUE READING

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