Ethanol-induced PGE2 up-regulates Aβ production through PKA/CREB signaling pathway.

Abstract

Ethanol abuse aggravates dementia-associated cognitive defects through the progression of Alzheimer's disease (AD) pathophysiology. Beta-site APP-cleaving enzyme 1 (BACE1) has been considered as a key regulator of AD pathogenesis by controlling amyloid beta peptide (Aβ) accumulation. In addition, previous studies reported that endoplasmic reticulum (ER… (More)
DOI: 10.1016/j.bbadis.2017.06.020

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