Ethanol extract of Psoralea corylifolia L. and its main constituent, bakuchiol, reduce bone loss in ovariectomised Sprague-Dawley rats.

@article{Lim2009EthanolEO,
  title={Ethanol extract of Psoralea corylifolia L. and its main constituent, bakuchiol, reduce bone loss in ovariectomised Sprague-Dawley rats.},
  author={Sun-Hye Lim and T N Ha and S. Kim and Jiyun Ahn and Hyun Jin Park and Suna Kim},
  journal={The British journal of nutrition},
  year={2009},
  volume={101 7},
  pages={1031-9}
}
The aim of the present study was to investigate whether ethanol extracts of Psoralea corylifolia L. (PCE) and its active component protect against bone loss in ovariectomised rats. We screened oestrogenic activities of the main extract fractions using in vitro assays and identified bakuchiol as the most active oestrogenic component by HPLC and LC/MS, and then demonstrated that bakuchiol had strong binding affinity for oestrogen receptor (ER) alpha. Seventy female Sprague-Dawley rats were… CONTINUE READING
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