Ethanol extract of Cnidium officinale exhibits anti-inflammatory effects in BV2 microglial cells by suppressing NF-κB nuclear translocation and the activation of the PI3K/Akt signaling pathway.

@article{Lee2013EthanolEO,
  title={Ethanol extract of Cnidium officinale exhibits anti-inflammatory effects in BV2 microglial cells by suppressing NF-$\kappa$B nuclear translocation and the activation of the PI3K/Akt signaling pathway.},
  author={Shin-Hwa Lee and Jun Hyuk Lee and Eun Young Oh and Gi-Young Kim and Byung Tae Choi and Cheolmin Kim and Yung-Hyun Choi},
  journal={International journal of molecular medicine},
  year={2013},
  volume={32 4},
  pages={
          876-82
        }
}
Chronic microglial activation endangers neuronal survival through the release of various toxic pro-inflammatory molecules; thus, negative regulators of microglial activation have been identified as potential therapeutic candidates for several neurological diseases. In this study, we investigated the inhibitory effects of an ethanol extract of Cnidium officinale rhizomes (EECO), which has been used as a herbal drug in Oriental medicine, on the production of lipopolysaccharide (LPS)-induced pro… 
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