Ethanol exposure decreases mitochondrial outer membrane permeability in cultured rat hepatocytes.

@article{Holmuhamedov2009EthanolED,
  title={Ethanol exposure decreases mitochondrial outer membrane permeability in cultured rat hepatocytes.},
  author={Ekhson Holmuhamedov and John J. Lemasters},
  journal={Archives of biochemistry and biophysics},
  year={2009},
  volume={481 2},
  pages={226-33}
}
Mitochondrial metabolism depends on movement of hydrophilic metabolites through the mitochondrial outer membrane via the voltage-dependent anion channel (VDAC). Here we assessed VDAC permeability of intracellular mitochondria in cultured hepatocytes after plasma membrane permeabilization with 8 microM digitonin. Blockade of VDAC with Koenig's polyanion inhibited uncoupled and ADP-stimulated respiration of permeabilized hepatocytes by 33% and 41%, respectively. Tenfold greater digitonin (80… CONTINUE READING
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