Ethanol enhances GABAergic transmission onto dopamine neurons in the ventral tegmental area of the rat.

@article{Theile2008EthanolEG,
  title={Ethanol enhances GABAergic transmission onto dopamine neurons in the ventral tegmental area of the rat.},
  author={Jonathan W Theile and Hitoshi Morikawa and Reuben A Gonzales and Richard A. Morrisett},
  journal={Alcoholism, clinical and experimental research},
  year={2008},
  volume={32 6},
  pages={1040-8}
}
BACKGROUND Activation of the dopaminergic (DA) neurons of the ventral tegmental area (VTA) by ethanol has been implicated in its rewarding and reinforcing effects. At most central synapses, ethanol generally increases inhibitory synaptic transmission; however, no studies have explored the effect of acute ethanol on GABAergic transmission in the VTA. METHODS Whole-cell patch clamp recordings of inhibitory postsynaptic currents (IPSCs) from VTA-DA neurons in midbrain slices from young rats… CONTINUE READING

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