Ethanol enhancement of GABA-induced 36Cl- influx does not involve changes in Ca2+.

Abstract

The effect of changes in intracellular Ca2+ on ethanol enhancement of GABA-mediated 36Cl- influx was investigated in mammalian cortical neurons in culture. Ethanol potentiated the effect of submaximal concentrations of GABA on the 36Cl- influx, and at 50 mM ethanol directly activated 36Cl- influx in these neurons. Pretreatment of the neurons with dantrolene (an agent that depletes intracellular Ca2+) and the Ca2+ ionophore, A 23187, did not alter the effect of GABA or ethanol enhancement of GABA-mediated 36Cl- influx. Together, these results suggest that changes in intracellular Ca2+ are not involved in ethanol modulation of GABAAergic responses in cortical neurons.

Statistics

0200400'00'02'04'06'08'10'12'14'16
Citations per Year

334 Citations

Semantic Scholar estimates that this publication has 334 citations based on the available data.

See our FAQ for additional information.

Cite this paper

@article{Mehta1994EthanolEO, title={Ethanol enhancement of GABA-induced 36Cl- influx does not involve changes in Ca2+.}, author={Ashok Kumar Mehta and Maharaj K. Ticku}, journal={Pharmacology, biochemistry, and behavior}, year={1994}, volume={47 2}, pages={355-7} }