Ethanol enhanced the genotoxicity of acrylamide in human, metabolically competent HepG2 cells by CYP2E1 induction and glutathione depletion.

@article{Lamy2008EthanolET,
  title={Ethanol enhanced the genotoxicity of acrylamide in human, metabolically competent HepG2 cells by CYP2E1 induction and glutathione depletion.},
  author={Evelyn Lamy and Yvonne V{\"o}lkel and P. Roos and F. Kassie and V. Mersch-Sundermann},
  journal={International journal of hygiene and environmental health},
  year={2008},
  volume={211 1-2},
  pages={
          74-81
        }
}
  • Evelyn Lamy, Yvonne Völkel, +2 authors V. Mersch-Sundermann
  • Published 2008
  • Medicine, Chemistry
  • International journal of hygiene and environmental health
  • In the present study, the genotoxicity of acrylamide (AA) was investigated in HepG2 cells using SCGE. Additionally, the influence of ethanol on the modulation of AA-induced DNA-migration caused by CYP2E1-upregulation and/or GSH-depletion was examined in the same cell line. For the ethanol/AA combination assays, the cells were treated with ethanol for 24h prior to exposure to 5mM AA for another 24h. 1.25 to 10mM AA-induced DNA migration (OTM) in HepG2 cells in a concentration-dependent manner, e… CONTINUE READING

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    References

    Publications referenced by this paper.
    SHOWING 1-10 OF 38 REFERENCES

    Genotoxicity of acrylamide in human lymphocytes.

    VIEW 1 EXCERPT

    Tissue-specific genotoxic effects of acrylamide and acrylonitrile.

    VIEW 1 EXCERPT

    Acrylamide-induced cellular transformation.

    VIEW 2 EXCERPTS

    Role of cytochrome P450 2E1 in the metabolism of acrylamide and acrylonitrile in mice.

    VIEW 1 EXCERPT