Ethanol drives aversive conditioning through dopamine 1 receptor and glutamate receptor-mediated activation of lateral habenula neurons.

@article{Zuo2017EthanolDA,
  title={Ethanol drives aversive conditioning through dopamine 1 receptor and glutamate receptor-mediated activation of lateral habenula neurons.},
  author={Wanhong Zuo and Rao Fu and Frederic Woodward Hopf and Guiqin Xie and Kre{\vs}imir Krnjevi{\'c} and Jing Rong Li and Jiang-hong Ye},
  journal={Addiction biology},
  year={2017},
  volume={22 1},
  pages={103-116}
}
There has been increasing interest in the lateral habenula (LHb) given its potent regulatory role in many aversion-related behaviors. Interestingly, ethanol can be rewarding as well as aversive; we therefore investigated whether ethanol exposure alters pacemaker firing or glutamate receptor signaling in LHb neurons in vitro and also whether LHb activity in… CONTINUE READING