Ethanol differentially enhances hippocampal GABA A receptor-mediated responses in protein kinase C gamma (PKC gamma) and PKC epsilon null mice.

@article{Proctor2003EthanolDE,
  title={Ethanol differentially enhances hippocampal GABA A receptor-mediated responses in protein kinase C gamma (PKC gamma) and PKC epsilon null mice.},
  author={William Ross Proctor and Wolfgang Poelchen and Barbara J. Bowers and Jeanne M. Wehner and Robert O Messing and Thomas V. Dunwiddie},
  journal={The Journal of pharmacology and experimental therapeutics},
  year={2003},
  volume={305 1},
  pages={264-70}
}
Ethanol intoxication results partly from actions of ethanol at specific ligand-gated ion channels. One such channel is the GABA(A) receptor complex, although ethanol's effects on GABA(A) receptors are variable. For example, we found that hippocampal neurons from selectively bred mice and rats with high hypnotic sensitivity to ethanol have increased GABA(A) receptor-mediated synaptic responses during acute ethanol treatment compared with mice and rats that display low behavioral sensitivity to… CONTINUE READING