Ethanol desensitizes cannabinoid CB1 receptors modulating monoamine synthesis in the rat brain in vivo

@article{Moranta2006EthanolDC,
  title={Ethanol desensitizes cannabinoid CB1 receptors modulating monoamine synthesis in the rat brain in vivo},
  author={D. Moranta and S. Esteban and J. Garc{\'i}a-Sevilla},
  journal={Neuroscience Letters},
  year={2006},
  volume={392},
  pages={58-61}
}
The endocannabinoid system and the cannabinoid CB(1) receptors are involved in the development of ethanol tolerance and dependence. This study aimed to investigate the in vivo sensitivity of a CB(1) receptor agonist (WIN 55,212-2) modulating the synthesis of 3,4-dihydroxy-phenylalanine/dopamine/noradrenaline (DOPA/DA/NA) and that of 5-hydroxy-tryptophan/serotonin (5-HTP/5-HT) in rat brain after ethanol treatment and withdrawal. In control rats, WIN 55,212-2 (4 mg/kg, i.p., for 1h), through a… Expand
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