Ethanol decreases zinc transfer to the fetus in normal but not metallothionein-null mice.

@article{Carey2000EthanolDZ,
  title={Ethanol decreases zinc transfer to the fetus in normal but not metallothionein-null mice.},
  author={Luke C. Carey and Peter Coyle and Jeffrey C. Philcox and Allan M. Rofe},
  journal={Alcoholism, clinical and experimental research},
  year={2000},
  volume={24 8},
  pages={1236-40}
}
BACKGROUND Ethanol causes significant teratogenicity in normal (MT+/+) but not metallothionein-null (MT-/-) fetuses. Impaired maternal fetal zinc (Zn) transfer is indicated, because ethanol significantly reduces plasma Zn concentrations in MT+/+ dams while increasing concentrations in MT-/- dams. In this study we examined maternal-fetal Zn homeostasis in response to ethanol in MT+/+ and MT-/- mice and the origins of the increase in plasma Zn in MT-/- mice. METHODS AND RESULTS Mice were… CONTINUE READING