Ethanol consumption inhibits fetal DNA methylation in mice: implications for the fetal alcohol syndrome.

@article{Garro1991EthanolCI,
  title={Ethanol consumption inhibits fetal DNA methylation in mice: implications for the fetal alcohol syndrome.},
  author={Anthony J. Garro and D. McBeth and Vanessa R Lima and Charles S. Lieber},
  journal={Alcoholism, clinical and experimental research},
  year={1991},
  volume={15 3},
  pages={395-8}
}
Acute ethanol administration (3 g/kg twice a day) to pregnant mice, from the 9th thru the 11th day of gestation, resulted in hypomethylation of fetal deoxyribonucleic acid (DNA). Nuclei isolated from the fetuses of the ethanol-treated mice had lower levels of methylase activity relative to controls even in the presence of excess S-adenosylmethionine, which serves as the methyl donor for the enzyme DNA methyltransferase. Acetaldehyde, at concentrations as low as 3 to 10 microM, inhibited DNA… CONTINUE READING