Ethanol consumption increases renal dysfunction and mortality in a mice model of sub-lethal sepsis.

@article{Vale2020EthanolCI,
  title={Ethanol consumption increases renal dysfunction and mortality in a mice model of sub-lethal sepsis.},
  author={G. T. do Vale and Sthefany T. Ricci and A. A. Silva and C. R. Tirapelli and C. S. Ceron},
  journal={Canadian journal of physiology and pharmacology},
  year={2020}
}
Chronic ethanol consumption and sepsis cause oxidative stress and renal dysfunction. This study aimed to examine whether chronic ethanol consumption sensitizes the mice kidney to sub-lethal cecal ligation and puncture (SL-CLP) sepsis, leading to impairment of renal function by tissue oxidative and inflammatory damage. Male C57BL/6J mice were treated for 9 weeks with ethanol (20% v/v), before SL-CLP was induced. Systolic blood pressure (SBP), survival rate, plasma creatinine, oxidative stress… Expand