Ethanol causes acute inhibition of carbohydrate, fat, and protein oxidation and insulin resistance.

@article{Shelmet1988EthanolCA,
  title={Ethanol causes acute inhibition of carbohydrate, fat, and protein oxidation and insulin resistance.},
  author={J J Shelmet and G. A. Reichard and C L Skutches and Robert Daniel Hoeldtke and Oliver E. Owen and Guenther Boden},
  journal={The Journal of clinical investigation},
  year={1988},
  volume={81 4},
  pages={1137-45}
}
To study the mechanism of the diabetogenic action of ethanol, ethanol (0.75 g/kg over 30 min) and then glucose (0.5 g/kg over 5 min) were infused intravenously into six normal males. During the 4-h study, 21.8 +/- 2.1 g of ethanol was metabolized and oxidized to CO2 and H2O. Ethanol decreased total body fat oxidation by 79% and protein oxidation by 39%, and almost completely abolished the 249% rise in carbohydrate (CHO) oxidation seen in controls after glucose infusion. Ethanol decreased the… CONTINUE READING
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