Ethanol and the NMDA receptor.

  title={Ethanol and the NMDA receptor.},
  author={Paula L. Hoffman and Carolyn Rabe and Kathleen A. Grant and P Valverius and Michael J. Hudspith and Boris Tabakoff},
  volume={7 3},
The actions of glutamate, the major excitatory amino acid in the CNS, are mediated by three receptor subtypes: kainate, quisqualate and N-methyl-D-aspartate (NMDA) receptors. Ethanol, in vitro, is a potent and selective inhibitor of the actions of agonists at the NMDA receptor. Following chronic ethanol ingestion, the number of NMDA receptor-ion channel complexes in certain brain areas is increased. This increase may contribute to the generation of ethanol withdrawal seizures, since… CONTINUE READING
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