Ethanol and signal transduction in the liver.

  title={Ethanol and signal transduction in the liver.},
  author={Jan B. Hoek and A. P. Thomas and Thomas A Rooney and Kyohei Higashi and Emanuel Rubin},
  journal={FASEB journal : official publication of the Federation of American Societies for Experimental Biology},
  volume={6 7},
The liver is a major target for both short- and long-term actions of ethanol. The mechanisms that mediate the response of cells and tissues to chronic intake of ethanol are unknown, but it is likely that both adaptive and deleterious responses are triggered by short-term interactions of the cell with ethanol. Cellular signaling processes are candidates to mediate the connection between short- and long-term actions of ethanol. Receptor-coupled signal transduction systems in the plasma membrane… CONTINUE READING

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