Ethanol and production of the hepatotoxic metabolite of acetaminophen in healthy adults.

@article{Thummel2000EthanolAP,
  title={Ethanol and production of the hepatotoxic metabolite of acetaminophen in healthy adults.},
  author={Kenneth E. Thummel and John T. Slattery and Han Ro and J. Y. L. Chien and Sidney D. Nelson and K E Lown and Paul B Watkins},
  journal={Clinical pharmacology and therapeutics},
  year={2000},
  volume={67 6},
  pages={591-9}
}
BACKGROUND Recent case reports suggest that consumption of ethanol may increase the risk of liver injury induced by acetaminophen (INN, paracetamol). However, this possibility is at odds with previous clinical studies that showed that acute ethanol ingestion could protect against hepatotoxicity by inhibiting CYP-mediated acetaminophen oxidation. We tested the hypothesis that ethanol ingestion can increase susceptibility to acetaminophen toxicity if acetaminophen ingestion occurs shortly after… CONTINUE READING