Ethanol and caffeine: A complex interaction with respect to locomotor activity and central catecholamines

@article{Waldeck1974EthanolAC,
  title={Ethanol and caffeine: A complex interaction with respect to locomotor activity and central catecholamines},
  author={Bertil Waldeck},
  journal={Psychopharmacologia},
  year={1974},
  volume={36},
  pages={209-220}
}
The effect of ethanol and caffeine on the locomotor activity (motility) of mice was investigated. Caffeine, 25 mg/kg, which by itself stimulated motility increased the stimulation of motility elicited by 1–2g/kg ethanol. When 3 g/kg ethanol was given, caffeine, 25 and 50 mg/kg, did not change the level of activity while 100 mg/kg abolished the increase in activity caused by ethanol alone. A mixture of ET495 and clonidine, which stimulate central dopamine and noradrenaline receptors respectively… CONTINUE READING