Ethanol and adult CNS neurodamage: oxidative stress, but possibly not excitotoxicity.

@article{Collins2012EthanolAA,
  title={Ethanol and adult CNS neurodamage: oxidative stress, but possibly not excitotoxicity.},
  author={Michael A. Collins and Edward J. Neafsey},
  journal={Frontiers in bioscience},
  year={2012},
  volume={4},
  pages={1358-67}
}
Evidence from experiments with adult rodents chronically treated with ethanol via either repetitive binges or continuous intake/exposure supports the occurrence of brain oxidative stress and, at least in binge intoxication/rat models, its essential causative role in neurodamage. However, pharmacological antagonism experiments reveal that N-methyl-D-aspartate (NMDA) receptor-dependent excitotoxicity is not responsible for adult mammalian brain neurodegeneration caused by repetitive binge ethanol… CONTINUE READING

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