Ethanol and acetaldehyde metabolism in the pregnant mouse.


Liver aldehyde dehydrogenase (ALDH) activity was found to be two-fold greater in pregnant (days 16-20 of gestation) mice than in non-pregnant controls. A subcellular fractionation revealed that the increase in ALDH activity was confined to the cystosolic fraction of the liver. Kinetic characterization of partially purified liver ALDH revealed similar Km… (More)


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