Ethanol and Arachidonic Acid Increase α2(I) Collagen Expression in Rat Hepatic Stellate Cells Overexpressing Cytochrome P450 2E1

@article{Nieto2000EthanolAA,
  title={Ethanol and Arachidonic Acid Increase $\alpha$2(I) Collagen Expression in Rat Hepatic Stellate Cells Overexpressing Cytochrome P450 2E1},
  author={N. Nieto and P. Greenwel and S. Friedman and F. Zhang and A. Dannenberg and A. Cederbaum},
  journal={The Journal of Biological Chemistry},
  year={2000},
  volume={275},
  pages={20136 - 20145}
}
The ability of ethanol and arachidonic acid (AA), as inducers of oxidative stress and key factors in alcoholic liver disease, to up-regulate alpha 2 collagen type I (COL1A2) gene expression was studied in a hepatic stellate cell line overexpressing the ethanol-inducible cytochrome P450 2E1 (CYP2E1) (E5 cells). A time- and dose-dependent induction in COL1A2 mRNA by ethanol or AA was observed that was prevented by diallylsulfide, a CYP2E1 inhibitor. Nuclear run-on experiments showed… Expand
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References

SHOWING 1-10 OF 57 REFERENCES
Dihydroxy Bile Acids Activate the Transcription of Cyclooxygenase-2*
Acetaldehyde increases collagen gene transcription in cultured human fibroblasts.
...
1
2
3
4
5
...