Ethanol administration produces divergent changes in GABAergic neuroactive steroid immunohistochemistry in the rat brain.

@article{Cook2014EthanolAP,
  title={Ethanol administration produces divergent changes in GABAergic neuroactive steroid immunohistochemistry in the rat brain.},
  author={Jason B Cook and Ana Maria G Dumitru and Todd K O'Buckley and A Leslie Morrow},
  journal={Alcoholism, clinical and experimental research},
  year={2014},
  volume={38 1},
  pages={90-9}
}
BACKGROUND The 5α-reduced pregnane neuroactive steroid (3α,5α)-3-hydroxypregnan-20-one (3α,5α-THP or allopregnanolone) is a potent positive modulator of GABAA receptors capable of modulating neuronal activity. In rats, systemic ethanol (EtOH) administration increases cerebral cortical and hippocampal levels of 3α,5α-THP, but the effects of EtOH on 3α,5α-THP levels in other brain regions are unknown. There is a large body of evidence suggesting that 3α,5α-THP enhances EtOH sensitivity… CONTINUE READING
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