Ethanol Induces Epigenetic Modulation of Prodynorphin and Pronociceptin Gene Expression in the Rat Amygdala Complex

  title={Ethanol Induces Epigenetic Modulation of Prodynorphin and Pronociceptin Gene Expression in the Rat Amygdala Complex},
  author={C. D'Addario and F. Caputi and T. Ekstr{\"o}m and M. Di Benedetto and M. Maccarrone and P. Romualdi and S. Candeletti},
  journal={Journal of Molecular Neuroscience},
  • C. D'Addario, F. Caputi, +4 authors S. Candeletti
  • Published 2012
  • Biology, Medicine
  • Journal of Molecular Neuroscience
  • Several studies demonstrated the role of the endogenous opioid system in the development of susceptibility to alcohol dependence. Recently, we reported that binge intragastric administration of ethanol induces selective alterations of pronociceptin and prodynorphin gene expression in the rat amygdala complex depending on the days of exposures and on the development of tolerance and dependence. The aim of the present study was to investigate the potential epigenetic mechanisms leading to these… CONTINUE READING
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