Ethanol Induces Epigenetic Modulation of Prodynorphin and Pronociceptin Gene Expression in the Rat Amygdala Complex

  title={Ethanol Induces Epigenetic Modulation of Prodynorphin and Pronociceptin Gene Expression in the Rat Amygdala Complex},
  author={Claudio D'Addario and Francesca Felicia Caputi and Tomas J. Ekstr{\"o}m and Manuela Di Benedetto and Mauro Maccarrone and Patrizia Romualdi and Sanzio Candeletti},
  journal={Journal of Molecular Neuroscience},
Several studies demonstrated the role of the endogenous opioid system in the development of susceptibility to alcohol dependence. Recently, we reported that binge intragastric administration of ethanol induces selective alterations of pronociceptin and prodynorphin gene expression in the rat amygdala complex depending on the days of exposures and on the development of tolerance and dependence. The aim of the present study was to investigate the potential epigenetic mechanisms leading to these… 

Advances in DNA, histone, and RNA methylation mechanisms in the pathophysiology of alcohol use disorder

This review summarizes one carbon metabolism and the mechanisms behind methylation of DNA, histones, and RNA and discusses the field's findings regarding alcohol’s global and gene-specific effects on methylation in the brain and liver and the resulting phenotypes characteristic of AUD.

DNA Epigenetics in Addiction Susceptibility

The notion that addiction susceptibility has an underlying DNA epigenetic basis has been discussed and evidence of cell type-specific, time dependent, and sex biased effects of drug use is reviewed.

The Molecular Basis of Alcohol Use Disorder (AUD). Genetics, Epigenetics, and Nutrition in AUD: An Amazing Triangle

This review connects gathered knowledge from three emerging fields—genetics, epigenetics, and nutrition—to form an amazing triangle relating to alcohol use disorder.

Transcriptional Regulators as Targets for Alcohol Pharmacotherapies.

This chapter will discuss transcriptional regulators that can be targeted pharmacologically and have shown some efficacy in attenuating alcohol consumption when targeted, and the epigenetic enzymes, the DNA methyltransferases and histone deacetylases, will be discussed.

Epigenetics of Stress, Addiction, and Resilience: Therapeutic Implications

  • J. Cadet
  • Psychology, Biology
    Molecular Neurobiology
  • 2014
The possibility that treatment of addiction should involve cognitive and pharmacological approaches that enhance resilience in at risk individuals is suggested and similar approaches should also be used with patients who have already succumbed to the nefarious effects of addictive substances.

The neurobiology of psychopathic traits in youths

  • R. Blair
  • Psychology, Biology
    Nature Reviews Neuroscience
  • 2013
Children with conduct disorder have psychopathic traits, which consist of a callous–unemotional component and an impulsive–antisocial component, which are associated with two core impairments.