Ethanol Depression of Cerebellar Purkinje Neuron Firing Involves Nicotinic Acetylcholine Receptors

@article{Freund1997EthanolDO,
  title={Ethanol Depression of Cerebellar Purkinje Neuron Firing Involves Nicotinic Acetylcholine Receptors},
  author={Ronald K. Freund and Michael R. Palmer},
  journal={Experimental Neurology},
  year={1997},
  volume={143},
  pages={319-322}
}
Local application of ethanol (EtOH) has been reported to inhibit Purkinje neuron firing. EtOH-induced depressions can be antagonized by bicuculline, suggesting involvement of GABAA receptors. Since there is evidence from other studies indicating that nicotine may interact with EtOH responses, in this study we investigated whether nicotinic acetylcholine receptors (nAChR's) might be also involved in EtOH-induced depressions of these neurons in urethane-anesthetized Sprague-Dawley rats. Using… CONTINUE READING