Ethanol 'dose-dependent' elimination: Michaelis-Menten v classical kinetic analysis.

  title={Ethanol 'dose-dependent' elimination: Michaelis-Menten v classical kinetic analysis.},
  author={R E Rangno and John H. Kreeft and Daniel S. Sitar},
  journal={British journal of clinical pharmacology},
  volume={12 5},
1 To compare classical linear regression techniques and a Michaelis-Menten elimination model eight normal human volunteers each received three intravenous doses (0.375, 0.5, and 0.75 g/kg) of ethanol and four of the subjects each received four oral doses (0.5, 0.65, 0.95, 1.25 g/kg) of ethanol. 2 Computerized analysis of the time-plasma concentration profiles using a two-compartment Michaelis-Menton elimination model yielded a median absorption constant of 1.29 h-1; volume of distribution of 0… CONTINUE READING
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