Ethanol: water mutually enhanced transdermal therapeutic system II: skin permeation of ethanol and nitroglycerin.

@article{Berner1989EthanolWM,
  title={Ethanol: water mutually enhanced transdermal therapeutic system II: skin permeation of ethanol and nitroglycerin.},
  author={Bret Berner and Gerard C. Mazzenga and Jeanette Otte and Reinhard Steffens and R H Juang and Chris Ebert},
  journal={Journal of pharmaceutical sciences},
  year={1989},
  volume={78 5},
  pages={402-7}
}
An optimal concentration range of aqueous ethanol produces 5-10-fold increases in nitroglycerin flux across skin and ethanol skin permeation that are far greater than reported previously. For aqueous ethanol solutions saturated with nitroglycerin with an ethanol volume fraction less than or equal to 0.7, the flux of nitroglycerin across skin is linear with the ethanol flux and is traced to a linear solubility relationship and a constant diffusion coefficient. 

From This Paper

Topics from this paper.
23 Citations
0 References
Similar Papers

Citations

Publications citing this paper.
Showing 1-10 of 23 extracted citations

Similar Papers

Loading similar papers…