Ethanol, sedative hypnotics, and glutamate receptor function in brain and cultured cells

@article{Tabakoff1993EthanolSH,
  title={Ethanol, sedative hypnotics, and glutamate receptor function in brain and cultured cells},
  author={Boris Tabakoff and Paula L. Hoffman},
  journal={Behavior Genetics},
  year={1993},
  volume={23},
  pages={231-236}
}
Ethanol, acutely, is a potent and selective inhibitor of the function of theN-methyl-d-aspartate (NMDA) subtype of glutamate receptor in primary cultures of cerebellar granule cells. The effect of ethanol can be reversed by high concentrations of glycine, and nonequilibrium ligand binding studies in brain membrane preparations suggest that ethanol may act by decreasing the frequency of ion channel opening. After chronic consumption of ethanol by animals, the number of NMDA receptors (measured… 

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