Ethambutol induces PKC-dependent cytotoxic and antiproliferative effects on human retinal pigment cells.

@article{Tsai2008EthambutolIP,
  title={Ethambutol induces PKC-dependent cytotoxic and antiproliferative effects on human retinal pigment cells.},
  author={Rong Kung Tsai and Chung Hsing Chang and Chi Ming Hseu and Shen Ming Chang and Jia-Ru Wu and H Z Wang and Wen Chen Wu and Wen Sheng Wu},
  journal={Experimental eye research},
  year={2008},
  volume={87 6},
  pages={594-603}
}
Ethambutol (EMB)-induced ocular side effects may involve the influence on functions of retinal pigment epithelium (RPE), in addition to EMB-induced optic neuropathy. To address this issue, the molecular and cellular effects of EMB on RPE including growth regulation, morphological responses, phagocytic activity, and the relevant signaling pathways were investigated. EMB (at optimal concentration 8.0mM) can trigger cell cycle arrest in both RPE50 and ARPE19 cells, accompanied by reduced DNA… CONTINUE READING