Ethacrynic acid inhibits transcellular NaCl reabsorption in dog kidneys in doses of 1 to 10 and proximal bicarbonate-dependent reabsorption at higher doses.


In anesthetized dogs, sodium reabsorption in the kidney tubule was continuously reduced with increasing dosage of ethacrynic acid until 59% of the filtered load was excreted with 25 at constant glomerular filtration rate. With 50, glomerular filtration rate fell, but fractional sodium reabsorption was further reduced by 7%. In the dosage… (More)


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