Etanercept decreases tumor necrosis factor-alpha activity in chronic wound fluid.

@article{Cowin2006EtanerceptDT,
  title={Etanercept decreases tumor necrosis factor-alpha activity in chronic wound fluid.},
  author={Allison J. Cowin and Nicholas Hatzirodos and Justin Rigden and Robert A Fitridge and David A. Belford},
  journal={Wound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair Society},
  year={2006},
  volume={14 4},
  pages={421-6}
}
High levels of tumor necrosis factor-alpha (TNF-alpha), a pro-inflammatory cytokine, are present in the wound fluid of chronic nonhealing wounds. This leads to increased inflammation, cytokine expression, and ultimately results in impaired wound healing and tissue destruction. Etanercept is a recombinant fusion protein that consists of the soluble TNF receptor (p75) linked to the Fc portion of human IgG1. It is an effective inhibitor of TNF-alpha and has been shown to provide rapid and… CONTINUE READING

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High levels of tumor necrosis factor - alpha ( TNF - alpha ) , a pro - inflammatory cytokine , are present in the wound fluid of chronic nonhealing wounds .
High levels of tumor necrosis factor - alpha ( TNF - alpha ) , a pro - inflammatory cytokine , are present in the wound fluid of chronic nonhealing wounds .
High levels of tumor necrosis factor - alpha ( TNF - alpha ) , a pro - inflammatory cytokine , are present in the wound fluid of chronic nonhealing wounds .
High levels of tumor necrosis factor - alpha ( TNF - alpha ) , a pro - inflammatory cytokine , are present in the wound fluid of chronic nonhealing wounds .
Etanercept is a recombinant fusion protein that consists of the soluble TNF receptor ( p75 ) linked to the Fc portion of human IgG1 .
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