Etanercept attenuates traumatic brain injury in rats by reducing early microglial expression of tumor necrosis factor-α

@inproceedings{Chio2012EtanerceptAT,
  title={Etanercept attenuates traumatic brain injury in rats by reducing early microglial expression of tumor necrosis factor-α},
  author={Chung-Ching Chio and Chin-Hong Chang and Che-Chuan Wang and Chong-Un Cheong and Chien-ming Chao and Bor-Chih Cheng and Chung-Zhing Yang and Ching-Ping Chang},
  booktitle={BMC Neuroscience},
  year={2012}
}
BackgroundTumor necrosis factor-alpha (TNF-α) is elevated early in injured brain after traumatic brain injury (TBI), in humans and in animals. Etanercept (a TNF-α antagonist with anti-inflammatory effects) attenuates TBI in rats by reducing both microglial and astrocytic activation and increased serum levels of TNF-α. However, it is not known whether etanercept improves outcomes of TBI by attenuating microglia-associated, astrocytes-associated, and/or neurons-associated TNF-α expression in… CONTINUE READING
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