Etanercept Restores the Antinociceptive Effect of Morphine and Suppresses Spinal Neuroinflammation in Morphine-Tolerant Rats

  title={Etanercept Restores the Antinociceptive Effect of Morphine and Suppresses Spinal Neuroinflammation in Morphine-Tolerant Rats},
  author={Ching-Hui Shen and Ru-Yin Tsai and Meng-Shen Shih and Shinn-Long Lin and Yueh-Hwa Tai and C C Chien and Chih-Shung Wong},
  journal={Anesthesia \& Analgesia},
BACKGROUND:In the present study we examined the effect of the tumor necrosis factor (TNF)-&agr; antagonist etanercept on the antinociceptive effect of morphine in morphine-tolerant rats. METHODS:Male Wistar rats were implanted with 2 intrathecal catheters, and 1 was connected to a mini-osmotic pump for either morphine (15 &mgr;g/h) or saline (1 &mgr;L/h) infusion for 5 days. On day 5, either etanercept (5 &mgr;g, 25 &mgr;g, and 50 &mgr;g/10 &mgr;L) or saline (10 &mgr;L) was injected via the… 

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