Et3N-catalyzed tandem formal [4 + 3] annulation/decarboxylation/isomerization of methyl coumalate with imine esters: access to functionalized azepine derivatives.

Abstract

An unprecedented catalytic tandem formal [4 + 3] cycloaddition/decarboxylation/isomerization of methyl coumalate and imine esters is successfully developed. This tandem reaction only requires Et3N as the mild base affording a series of highly functionalized seven-membered heterocyclic azepine derivatives in good yields with excellent regioselectivities.

DOI: 10.1021/ol5020569

Cite this paper

@article{Liu2014Et3NcatalyzedTF, title={Et3N-catalyzed tandem formal [4 + 3] annulation/decarboxylation/isomerization of methyl coumalate with imine esters: access to functionalized azepine derivatives.}, author={Kang Liu and Huai-Long Teng and Chun-Jiang Wang}, journal={Organic letters}, year={2014}, volume={16 17}, pages={4508-11} }