Et-A receptor antagonist BQ123 prevents radiocontrast media-induced renal medullary hypoxia.

@article{Liss2003EtARA,
  title={Et-A receptor antagonist BQ123 prevents radiocontrast media-induced renal medullary hypoxia.},
  author={Per Liss and P O Carlsson and Anders Nygren and Fredrik Palm and Peter Hansell},
  journal={Acta radiologica},
  year={2003},
  volume={44 1},
  pages={111-7}
}
PURPOSE Renal vasoconstriction with resultant tissue hypoxia, especially in the renal medulla, has been suggested to play a role in contrast media (CM)-induced nephropathy. Endothelin (ET) is released into the blood stream following CM injection and has been proposed as a potential mediator through its vasoconstrictive properties. MATERIAL AND METHODS To investigate the possible protective influence of ET-receptor antagonists against CM-induced reduction in renal function, we studied the… CONTINUE READING