• Corpus ID: 208603522

Estudios biodirigidos leishmanicidas y tripanocidas de plantas amazónicas: cultura Tacana

@inproceedings{Tovar2019EstudiosBL,
  title={Estudios biodirigidos leishmanicidas y tripanocidas de plantas amaz{\'o}nicas: cultura Tacana},
  author={Camila Isabel Palma Tovar and Alberto tutor Gimenez Turba},
  year={2019}
}

• Camila Isabel Palma Tovar, Alberto tutor Gimenez Turba
• Published 2019
• Biology

Chagas disease and the leishmaniasis are forgoten tropical diseases that are endemic in our country. One of the challenges is to find new effective and less toxic therapies; within that frame our Faculty has been evaluating the tacana traditional medicine as a source of potential antiparasitic agents. Aim: To contribute to the validation of the amazonic traditional medicine generating scientific knowledge through bioguided chemical studies of vegetal species used by the tacana culture, useful in the development of new leishmanicidal and tripanocidal treatments. Methodology: Eight medicinal species were evaluated and divided in three groups in function of the advances on the bioguided fractionation and components identification. The tripanocidal and leishmanicidal activity was evaluated by a colorimetric assay while the cytotoxicity was determined on HeLa cells and PBMCs (Peripheral Blood Mononuclar Cells), using a fluorometric assay. Results and Conclusions: The bioguided fractionation allowed to distinguish Cheperequi (Jacaranda glabra) as interesting. In the biological evaluation of fractions with chemical identity, Cawuara (Tessaria integrifolia) allowed the isolation of eudesmanes[57] and [60], a mixture of terpenoids[56] and a sesquiterpen+amine mixture[62] with antiparasitic activity. Tapacha ina (Hypts mutabilis) allowed the isolation of olguin[32] with antiparasitic activity. Within the hemisintetic derivatives of Yuruma huana dheja (Dendropanax arboreus) the isorhamnetin derivative[80] was a potential leishmanicidal agent.