Estrous cycle variation of TRPV1-mediated cross-organ sensitization between uterus and NMDA-dependent pelvic-urethra reflex activity.

@article{Peng2008EstrousCV,
  title={Estrous cycle variation of TRPV1-mediated cross-organ sensitization between uterus and NMDA-dependent pelvic-urethra reflex activity.},
  author={Hsien-Yu Peng and Pei-chen Huang and Jiuan-Miaw Liao and K R Tung and Shin-Da Lee and Chen-Li Cheng and Jyh-Cherng Shyu and Cheng-Yuan Lai and Gin-Den Chen and T Lin},
  journal={American journal of physiology. Endocrinology and metabolism},
  year={2008},
  volume={295 3},
  pages={
          E559-68
        }
}
Cross-organ sensitization between the uterus and the lower urinary tract (LUT) underlies the high concurrence of pelvic pain syndrome and LUT dysfunctions, and yet the role of gonadal steroids is still unknown. We tested the hypothesis that cross-organ sensitization on pelvic-urethra reflex activity caused by uterine capsaicin instillation is estrous cycle dependent. When compared with the baseline reflex activity (1.00 +/- 0.00 spikes/stimulation), uterine capsaicin instillation significantly… CONTINUE READING

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