Estrous cycle variation in anxiolytic-like effects of topiramate in Wistar rats in two animal models of anxiety-like behavior.

@article{MolinaHernndez2013EstrousCV,
  title={Estrous cycle variation in anxiolytic-like effects of topiramate in Wistar rats in two animal models of anxiety-like behavior.},
  author={Miguel Molina-Hern{\'a}ndez and Norma Patricia T{\'e}llez-Alc{\'a}ntara and Jorge Iv{\'a}n Olivera-Lopez and M. Teresa Jaramillo},
  journal={Pharmacology, biochemistry, and behavior},
  year={2013},
  volume={103 3},
  pages={631-6}
}
The anxiolytic-like effects of topiramate were assessed during several estrous cycle phases in Wistar rats tested in two animal models of anxiety-like behavior. In a conflict operant test, during proestrus, diazepam (1.3, 2.0mg/kg; P<0.05) or topiramate (20.0, 30.0mg/kg; P<0.05) increased the number of immediately punished responses. During metestrus… CONTINUE READING