Estrous cycle regulates activation of hippocampal Akt, LIM kinase, and neurotrophin receptors in C57BL/6 mice.

@article{Spencer2008EstrousCR,
  title={Estrous cycle regulates activation of hippocampal Akt, LIM kinase, and neurotrophin receptors in C57BL/6 mice.},
  author={Joanna L Spencer and Elizabeth M. Waters and Teresa A Milner and Bruce S. McEwen},
  journal={Neuroscience},
  year={2008},
  volume={155 4},
  pages={1106-19}
}
Estradiol modulates dendritic spine morphology and synaptic protein expression in the rodent hippocampus, as well as hippocampal-dependent learning and memory. In the rat, these effects may be mediated through nongenomic steroid signaling such as estradiol activation of the Akt and LIM kinase (LIMK) pathways, in addition to genomic signaling involving estradiol upregulation of brain-derived neurotrophic factor expression (BDNF). Due to the many species differences between mice and rats… CONTINUE READING