Estrogens synthesized and acting within a spinal oligomer suppress spinal endomorphin 2 antinociception: ebb and flow over the rat reproductive cycle.

Abstract

The magnitude of antinociception elicited by intrathecal endomorphin 2 (EM2), an endogenous mu-opioid receptor (MOR) ligand, varies across the rat estrous cycle. We now report that phasic changes in analgesic responsiveness to spinal EM2 result from plastic interactions within a novel membrane-bound oligomer containing estrogen receptors (mERs), aromatase… (More)
DOI: 10.1097/j.pain.0000000000000991

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@article{Liu2017EstrogensSA, title={Estrogens synthesized and acting within a spinal oligomer suppress spinal endomorphin 2 antinociception: ebb and flow over the rat reproductive cycle.}, author={Nai-Jiang Liu and Vijaya Murugaiyan and Emiliya M Storman and Stephen A Schnell and Martin W Wessendorf and Alan R. Gintzler}, journal={Pain}, year={2017}, volume={158 10}, pages={1903-1914} }