Estrogens participate in the antidepressant-like effect of desipramine and fluoxetine in male rats.

@article{Luca2008EstrogensPI,
  title={Estrogens participate in the antidepressant-like effect of desipramine and fluoxetine in male rats.},
  author={Mart{\'i}nez-Mota Luc{\'i}a and Jos{\'e} Juan Cruz-Mart{\'i}nez and Sergio M{\'a}rquez-Baltazar and Alonso Fern{\'a}ndez-Guasti},
  journal={Pharmacology, biochemistry, and behavior},
  year={2008},
  volume={88 3},
  pages={332-40}
}
In male rats, the antidepressant-like effect of fluoxetine (FLX) and desipramine (DMI) in the forced swimming test (FST) is reduced by orchidectomy and partially restored by testosterone (T). It is unknown if this modulation of T is produced by its estrogenic metabolites. The objectives of this study were to evaluate if the aromatase inhibitor, formestane, interferes with the antidepressant-like effect of DMI and FLX in intact male rats, and to analyze if 17beta-estradiol (E2) modifies the FST… CONTINUE READING

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