Estrogens increase cystathionine-γ-lyase expression and decrease inflammation and oxidative stress in the myocardium of ovariectomized rats.

@article{Zhu2013EstrogensIC,
  title={Estrogens increase cystathionine-γ-lyase expression and decrease inflammation and oxidative stress in the myocardium of ovariectomized rats.},
  author={Xiaoyan Zhu and Zhiping Tang and Binghai Cong and Jiankui Du and Changnan Wang and Long Wang and Xin Ni and Jianqiang Lu},
  journal={Menopause},
  year={2013},
  volume={20 10},
  pages={1084-91}
}
OBJECTIVE Hydrogen sulfide (H2S), generated in the myocardium predominantly via cystathionine-γ-lyase (CSE), is cardioprotective. The objectives of the present study were to investigate the effects of estrogens on CSE expression and H2S generation in the myocardium and to examine whether serum 17β-estradiol (E2) level is associated with CSE activity and H2S generation and whether H2S or E2 level is associated with proinflammatory cytokines and oxidative stress status. METHODS Ovariectomized… CONTINUE READING