Estrogens in testis biology.

  title={Estrogens in testis biology.},
  author={Jayne E Sierens and Sharon F Sneddon and Frances Collins and Michael R Millar and Philippa T. K. Saunders},
  journal={Annals of the New York Academy of Sciences},
Levels of estrogen within the male reproductive tract are higher than in the general circulation and the aromatase enzyme is expressed in the adult testis. Estrogens such as estradiol (E2) modify cell function by binding to high-affinity estrogen receptors (ER). Two subtypes (ERalpha and ERbeta) have been identified. Studies in animals have shown that over- or underexposure to estrogens can have an impact on testis function. For example, mice with targeted disruption of the aromatase cyp19 gene… CONTINUE READING