Estrogens in Testis Biology

  title={Estrogens in Testis Biology},
  author={Jayne E. Sierens and S. F. Sneddon and F. Collins and M. Millar and P. T. K. Saunders},
  journal={Annals of the New York Academy of Sciences},
  • Jayne E. Sierens, S. F. Sneddon, +2 authors P. T. K. Saunders
  • Published 2005
  • Biology, Medicine
  • Annals of the New York Academy of Sciences
  • Abstract: Levels of estrogen within the male reproductive tract are higher than in the general circulation and the aromatase enzyme is expressed in the adult testis. Estrogens such as estradiol (E2) modify cell function by binding to high‐affinity estrogen receptors (ER). Two subtypes (ERα and ERβ) have been identified. Studies in animals have shown that over‐ or underexposure to estrogens can have an impact on testis function. For example, mice with targeted disruption of the aromatase cyp19… CONTINUE READING
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