Estrogens and selective estrogen receptor modulators in acromegaly

@article{Duarte2016EstrogensAS,
  title={Estrogens and selective estrogen receptor modulators in acromegaly},
  author={F. Duarte and R. Jallad and M. Bronstein},
  journal={Endocrine},
  year={2016},
  volume={54},
  pages={306-314}
}
Despite recent advances in acromegaly treatment by surgery, drugs, and radiotherapy, hormonal control is still not achieved by some patients. The impairment of IGF-1 generation by estrogens in growth hormone deficient patients is well known. Patients on oral estrogens need higher growth hormone doses in order to achieve normal IGF-1 values. In the past, estrogens were one of the first drugs used to treat acromegaly. Nevertheless, due to the high doses used and the obvious side effects in male… Expand
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Methods Citations
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11 Citations

Citation Type

Citation Type

The significance of estrogen receptors in acromegaly: Are they useful as predictors of prognosis and therapy regimen?
  • Selma Ozturk, H. Donmez-Altuntas, +4 authors F. Bayram
  • Medicine
  • Growth hormone & IGF research : official journal of the Growth Hormone Research Society and the International IGF Research Society
  • 2020
TLDR
The results indicated that the high ESR1 and ESR2 gene expressions in acromegaly patients are associated to the decrease of pre-operative IGF-1 values and an inverse association was found between the pre-operatively insulin-like growth factor-1 (IGF-1) levels and the expressions of ESR 1/ESR2 gene in acRomegaly Patients. Expand
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Silent growth hormone adenomas (SGHA) are a rare entity of non-functioning pituitary neuroendocrine tumors that are often uncovered by investigation for headaches or oligoamenorrhea. Expand
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Treatment of cells with SERMs caused cell apoptosis, as demonstrated by Caspase 3/7 activity and western blot assays, and the general applicability of SERMs for pituitary adenoma cells might be promising in clinical applications for the treatment of pituitARY adenomas. Expand
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The different etiologies of hypopituitarism are discussed and one by one the clinical aspects, diagnostic evaluation, and therapeutic options for deficiencies of TSH, ACTH, gonadotropin, and GH are addressed. Expand
Gender differences and temporal trends over two decades in acromegaly: a single center study in 112 patients
TLDR
Gender-specific characteristics and an evolving spectrum of clinical presentation with implications for earlier diagnosis and personalized management of acromegaly are demonstrated. Expand
Acromegaly: Current Challenges and Future Directions in Latin America
Acromegaly is a rare disease, associated with significant morbidity and high mortality. The international literature provides different figures on the epidemiology of acromegaly in different… Expand
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Efficiency of substituting conventional gonadotropin-based superovulation with a clomiphene-based regimen in goats was investigated, and does that exhibited estrus were naturally mated soon after GnRH treatment and 24 h later. Expand
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