Estrogens and selective estrogen receptor modulators in acromegaly

@article{Duarte2016EstrogensAS,
  title={Estrogens and selective estrogen receptor modulators in acromegaly},
  author={Felipe H. G. Duarte and Raquel Soares Jallad and Marcello Delano Bronstein},
  journal={Endocrine},
  year={2016},
  volume={54},
  pages={306-314}
}
Despite recent advances in acromegaly treatment by surgery, drugs, and radiotherapy, hormonal control is still not achieved by some patients. The impairment of IGF-1 generation by estrogens in growth hormone deficient patients is well known. Patients on oral estrogens need higher growth hormone doses in order to achieve normal IGF-1 values. In the past, estrogens were one of the first drugs used to treat acromegaly. Nevertheless, due to the high doses used and the obvious side effects in male… 
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