Estrogens and selective estrogen receptor modulators in acromegaly

  title={Estrogens and selective estrogen receptor modulators in acromegaly},
  author={F. H. Duarte and R. Jallad and M. Bronstein},
  • F. H. Duarte, R. Jallad, M. Bronstein
  • Published 2016
  • Medicine
  • Endocrine
  • Despite recent advances in acromegaly treatment by surgery, drugs, and radiotherapy, hormonal control is still not achieved by some patients. The impairment of IGF-1 generation by estrogens in growth hormone deficient patients is well known. Patients on oral estrogens need higher growth hormone doses in order to achieve normal IGF-1 values. In the past, estrogens were one of the first drugs used to treat acromegaly. Nevertheless, due to the high doses used and the obvious side effects in male… CONTINUE READING
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