Estrogens and health in males

@article{Lombardi2001EstrogensAH,
  title={Estrogens and health in males},
  author={Gaetano Lombardi and Stefano Zarrilli and Annamaria Colao and Luigi Paesano and Carolina di Somma and F W Rossi and Michele De Rosa},
  journal={Molecular and Cellular Endocrinology},
  year={2001},
  volume={178},
  pages={51-55}
}
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79 Citations
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Endocrine , Reproductive , Neurophysiologic and Extraneous Activities of Estrogen in Vertebrates
Estrogens are reproductive hormones synthesized in the gonads of both male and female vertebrates. This review is geared towards uncovering some endocrine, reproductive, neurophysiologic and…
Estrogens and spermatogenesis.
  • C. Shaha
  • Medicine, Biology
    Advances in experimental medicine and biology
  • 2008
TLDR
It is now established that estrogens are involved in numerous physiological processes in the male, for example, bone turnover, behavior and the cardiovascular system, but controversy exists as to whether male fertility over the past five decades has truly shown a decline due to the relatively low levels of estrogens in the environment than humans are exposed to.
Interaction with estrogen receptors as treatment of arthritis and osteoporosis.
  • H. Carlsten
  • Medicine
    Advances in experimental medicine and biology
  • 2007
TLDR
There is great need for new activators of estrogen receptors (ERs) selectively reproducing only the beneficial effects of estrogen, to understand the mechanisms for estrogen mediated effects on bone loss in inflammatory diseases.
Comparison of tamoxifen and testosterone propionate in male rats: differential prevention of orchidectomy effects on sex organs, bone mass, growth, and the growth hormone-IGF-I axis.
TLDR
Tamoxifen prevented ORX effects on bone and cholesterol in male rats without affecting sex organs or PRL and might be useful for men who must avoid androgens.
Effects of chrysin on urinary testosterone levels in human males.
TLDR
The use of these foods for 21 days at the doses usually taken as oral supplementation does not have effects on the equilibrium of testosterone in human males, and chrysin could block the conversion of androgens into estrogens with a consequent increase of testosterone, eventually measurable in urine samples.
Localization of Estrogen Receptors in Male Reproductive Tissues and Sperm Cells – A Review
TLDR
The ER detection in male reproductive tissues and sperm cells at different development stages is described in representative mammalian species (human, mouse, rat, horse, and pig), in which the ER localization has been most described.
The human testes: Estrogen and ageing outlooks
Mechanisms of estrogen effects on the endothelium: an overview.
Immune responses and bone loss: the estrogen connection
TLDR
There is great need for new activators of estrogen receptors (ERs) selectively reproducing only the beneficial effects of estrogen, and better knowledge of the mechanisms of how activation of ER‐α and ER‐β modulates the immune system and bone at the cellular and molecular levels is necessary.
Early Exposure to Genistein Exerts Long-Lasting Effects on the Endocrine and Immune Systems in Rats
TLDR
Exposure to genistein during pregnancy and lactation exerts long-lasting effects on the endocrine and immune systems in adulthood, and whether exposure to phytoestrogens during early development affects responses to infectious or autoimmune diseases, as well as cancers, later in life requires investigation.
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References

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TLDR
Study of the mutations in CYP19, the gene encoding aromatase, in six females and two males and a mutant estrogen receptor alpha in a man provide illuminating new insights into the critical role of estrogen in the male in the pubertal growth spurt and skeletal maturation, and in the importance of estrogen sufficiency in the accrual and maintenance of bone mass.
The Roles of Oestrogen in the Male
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  • Biology, Medicine
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Perinatal exposure to estrogenic compounds and the subsequent effects on the prostate of the adult rat: evaluation of inflammation in the ventral and lateral lobes.
Phytoestrogens: Potential Endocrine Disruptors in Males
Exposure to diethylstilbestrol (DES) induces persistent structural and functional alterations in the developing reproductive tract of males. It is possible that xenoestrogens other than DES alter…
A role for oestrogens in the male reproductive system
TLDR
It is shown that oestrogen regulates the reabsorption of luminal fluid in the head of the epididymis, which raises further concern over the potential direct effects of environmental oestrogens on male reproduction and reported declines in human sperm counts.
Estrogenic induction of spermatogenesis in the hypogonadal mouse.
TLDR
The identification of effects of estradiol on testicular function provides a conceptual basis to reexamine the speculative link between increased exposure to environmental estrogens and reduced fertility in man and indicates that estrogens may play a role in spermatogenesis, via stimulatory effects on FSH secretion.
Estrogen resistance caused by a mutation in the estrogen-receptor gene in a man.
TLDR
Disruption of the estrogen receptor in humans need not be lethal and is important for bone maturation and mineralization in men as well as women.
Estrogens, Blood Pressure, and Cardiovascular Diseases
TLDR
Most studies have demonstrated that postmenopausal estrogen use either has no effect on or causes a slight reduction in blood pressure, but the mechanism of estrogen's protective effect is in part related to its favorable effect on lipoproteins.
Arterial reactivity is enhanced in genetic males taking high dose estrogens.
Effect of testosterone and estradiol in a man with aromatase deficiency.
TLDR
The responses to androgen and estrogen in a man with a novel, homozygous inactivating mutation of cytochrome P-450 aromatase suggest a crucial role of estrogen in skeletal maturation.
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