Estrogens and atherosclerosis: insights from animal models and cell systems.

  title={Estrogens and atherosclerosis: insights from animal models and cell systems.},
  author={J R Nofer},
  journal={Journal of molecular endocrinology},
  volume={48 2},
Estrogens not only play a pivotal role in sexual development but are also involved in several physiological processes in various tissues including vasculature. While several epidemiological studies documented an inverse relationship between plasma estrogen levels and the incidence of cardiovascular disease and related it to the inhibition of atherosclerosis, an interventional trial showed an increase in cardiovascular events among postmenopausal women on estrogen treatment. The development of… CONTINUE READING
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